The interaction of factor VIIa with rehydrated, lyophilized platelets

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چکیده

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Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion.

Currently, therapeutic platelet concentrates can be stored for only 5 days. We have developed a procedure that permits long-term storage of fixed and lyophilized platelets that retain hemostatic properties after rehydration. These rehydrated lyophilized platelets (RL platelets) restore hemostasis in thrombocytopenic rats and become incorporated in the hemostatic plug of bleeding time wounds of ...

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Coagulation factor interaction with platelets.

Since the initial observation that bleeding is stopped by a platelet plug, it has been clear that platelets play an important role in hemostasis. Patients with very low platelet counts (thrombocytopenia) or with disfunctional platelets have a bleeding diathesis. With the further observation that the platelet plug becomes interwoven with fibrin, it has become clear that platelets interact with t...

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15 صفحه اول

Factor VIIa-mediated tenase function on activated platelets under flow.

BACKGROUND Tissue factor (TF) and/or active factor (F)VIIa may be stored inside resting platelets. OBJECTIVES The objective of this study was to examine if platelets, following activation of GPVI, could support tenase and prothrombinase activity without any exogenously added tissue factor. METHODS Thrombin (IIa) formation on gel-filtered platelets with added factors or the clotting of plate...

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ژورنال

عنوان ژورنال: Platelets

سال: 2008

ISSN: 0953-7104,1369-1635

DOI: 10.1080/09537100701493794